Semaglutide was associated with significantly reduced risk for first-time AD diagnosis, most strongly compared with insulin (hazard ratio [HR], 0.33 [95% CI: 0.21 to 0.51]) and most weakly compared with other GLP-1RAs (HR, 0.59 [95% CI: 0.37 to 0.95]). Similar results were seen across obesity status, gender, and age groups.
I haven’t done a deep dive in a while, but last I checked there was some thinking that Alzheimers may be caused by inflammation possibly brought on by a leaky blood-brain barrier, and IIRC this was proposed as why eating a poor diet and/or having diabetes is such a risk factor.
I probably should research the topic again, I have a hereditary high risk of Alzheimers, although granted so did my dad and it didn’t get him til his mid 80s.
Anyway… odds on whether this replicates?
Odds of low-frequency horrible side effects to GLP-1 drugs being found?