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this has been known among users of these drugs for quite a while now. They bond to the same receptors, so they interfere with each other. You can mitigate this a bit by going 24 hours without your SSRI/SNRI (ie skipping the dose that would precede the trip), and increasing dose of the psilocybin by ~1.5x. Or so I hear
Also pretty dangerous to do MDMA without pausing your SSRIs and just about deadly to do them when on MAOIs
true, but MDMA is a different drug
Yeah, but its a serotonin agonist, so it has a compounding effect
Oh yes. Antidepressants have definitely reduced the effectiveness of various drugs for me.
Can confirm.
