Seinfeld- Jerry and Elaine are exes and breify get back together at the end of season one
Friends- lots of romantic entaglements but mainly Chandler/Monica, Ross/Rachel, and Joey/Rachel
How I Met Your Mother - two of the main characters are a steady couple, the other three are a love triangle
Big Bang Theory- by the end, it’s three couples and one single guy
Any shows like these where the main characters never date each other or hook up with each other?
Seems like that depends on a group of screenwriters with a masochistic enjoyment of denial. You have to think it would be a very tempting subplot to start.
As a result, most of the ideas people here have involve like three main characters. I’m not sure about 30 Rock.