• gallopingsnail
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    5 days ago

    Neither of these are true for acetaminophen/paracetamol though?

    • Jax@sh.itjust.works
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      5 days ago

      You can build a tolerance to both of those things, but their painkilling effectiveness is just not as strong as opiates.

      • gallopingsnail
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        5 days ago

        Both of those are the same thing, and any chance of developing tolerance is very low.

        • Jax@sh.itjust.works
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          5 days ago

          Sorry, I was very tired - however, having taken ibuprofen for years - 2 pills will not give me the same pain relief as it did 10 years ago. I have to up it to 3, or 4. I’m not sure if this is tolerance or an increase in inflammation resulting in a need for a higher dose (hoping not).

    • petrol_sniff_king@lemmy.blahaj.zone
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      5 days ago

      Not that I would know, but don’t all medications build up tolerance?

      Like, I was under the impression that medicinal benefits are like a side-effect to what the body might otherwise consider a foreign pathogen. Does acetaminophen not trigger any immune response?

      • gallopingsnail
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        5 days ago

        With some exceptions for medications that use the immune system to target therapy (such as monoclonal antibodies) or drugs that target the immune system specifically, there is no immune response to most medications.