They’re also part of the rising surveillance state. Fuck these cameras.

The cone snail referenced in the study you linked, Conus geographus, also has the same ion channel disrupting venom that is typical of cone snails. If you were bit by one, you’d die of paralysis. It does appear to use an insulin-like peptide to initially stun the fish, but the coup de grâce is from typical paralytic conotoxins.

A cool discovery nonetheless and TIL. Neat.

https://pubmed.ncbi.nlm.nih.gov/25301479/

Conus geographus is the most dangerous cone snail species known, with reported human fatality rates as high as 65%. Crude venom gland extracts have been used to determine animal LD50 and to aid the isolation of several potent paralytic toxins. […]The molecular composition of individual defense-evoked venom showed significant intraspecific variations, but a core of paralytic conotoxins including α-GI, α-GII, μ-GIIIA, ω-GVIA and ω-GVIIA was always present in large amounts, consistent with the symptomology and high fatality rate in humans.

Who’s smart enough to compile usernames off the subs listed throughout that thread?

I’m a former biochemist and my university studied conotoxins for use as analgesics. Cone snail venom as commonly understood are ion channel blockers. I’ve not heard of what you’re mentioning until now, but when you mention “cone snail venom”, most biology people are thinking of ion channel blockers. This is their primary method of disabling prey.

If you’re bit by a cone snail and try to drink some soda to counteract the toxin, you’re going to have a bad time. They’re called cigarette snails because you’ve got time to smoke one cig before you die - and not from low blood sugar.

From your source:

For example, fish-hunting cone snails use a “motor cabal” to disrupt the propagation of action potentials at the neuromuscular junction. Motor cabal toxins include those that block presynaptic voltage-gated calcium channels (CaV), postsynaptic nicotinic acetylcholine receptors (nAChR), and voltage-gated sodium channels (NaV) on muscle cells6.

From Wikipedia:

https://en.wikipedia.org/wiki/Conotoxin

As of 2005, five biologically active conotoxins have been identified. Each of the five conotoxins attacks a different target:

• α-conotoxin inhibits nicotinic acetylcholine receptorsat nerves and muscles.[11]
• δ-conotoxin inhibits fast inactivation of voltage-dependent sodium channels.[12]
• κ-conotoxin inhibits potassium channels.[13]
• μ-conotoxin inhibits voltage-dependent sodium channels in muscles.[14]
• ω-conotoxin inhibits N-type voltage-dependent calcium channels.[15] Because N-type voltage-dependent calcium channels are related to algesia(sensitivity to pain) in the nervous system, ω-conotoxin has an analgesic effect: the effect of ω-conotoxin M VII A is 100 to 1000 times that of morphine.[16] Therefore, a synthetic version of ω-conotoxin M VII A has found application as an analgesic drug ziconotide (Prialt).[17]

It’s got nothing to do with insulin or glucose levels, though. It blocks either sodium or potassium channels, can’t remember off the dome. Temporarily ruins the electrical conductivity of nerves.

Edit: I stand corrected.

Definitely try one stick.

It could be the CPU that’s bad - memory controller is on CPU these days. I’m not totally up to speed on AMD voltage names but I’d check whatever CPU voltage is for the memory controller as well as doing a single stick test.

Does it pass with one stick on XMP timings?

FWIW, I always set the main timings and voltage manually on my motherboard. My motherboard always gets the last timing wrong. I can’t recall the exact one ATM, but it’s auto set to like 52 rather than 36, something like that.

Ori isn’t bad. I’d not consider it “souls like” in the slightest.

There are amateur radio data protocols but it’s slow as fuck.

Ultimately, nothing is waterproof; everything leaks.

It’s a Soprano’s quote, when Chrissy is high as fuck at the wake rambling.

Other comment is wrong. LD50 = 50% chance of dying. LD99 = 99% chance of dying. The figures I listed are for humans, not mice. LD50 in mice is likely drastically different than LD50 in humans.

Your entire comment is incorrect. LD50 is lethal dose to kill on average 50% of the time. LD99 is the dose that kills 99% of people. The figures I listed are for humans. There’s no way to extrapolate LD50 from other species to humans. There is enough data on humans radiation exposure to directly calculate LD50.

Obviously that’s not possible, even with computers.

Edit: This is a Sopranos quote for shitposting purposes. I’m disappointed, Lemmy.

This costs “less than $70”.

You can get a cheap Geiger counter for $50 today and it’s about the same size. I see some for $30-40. These are based on old, proven technology, not some new thing with new unknown problems and an app.

Not that it isn’t neat, but it’s kind of a solved problem.

To put this into perspective, a 10 Gray dose to the skin is high enough to cause permanent hair loss.

A 10Gy exposure is well, well beyond hair loss range and into the fatal within days zone. The LD50 is 5Gy, LD99 is 9Gy IIRC. Methinks the author did not do their research on the topic.

None of the above, well maybe the last one. Plexamp has algorithmically generated playlists based off song/album/artist, decades, genres, top rated tracks, etc. including auto mixing with crossfading, and ability to choose tracks not only from your own libraries, but from all libraries shared with you.

This feature has done wonders for library discovery as I have an absolutely massive music stash. It’s completely replaced music discovery via streaming apps for me.

I really do appreciate all the efforts to inform me of JF features but I am quite happy with my setup currently, and I don’t want to reconfigure all my shit AND get 12 n users to switch apps. It was hard enough as it is.

More like the opposite idea. These are for discharging built up static electricity from the plane back to the air.

Oh man do I ever miss methoxetamine

That is metabolism. CICO will make literally anyone gain or lose weight. Nothing in the universe violates thermodynamics. You maintain a healthy caloric deficit and lose weight. End of story.

Not eating anything for a month is an eating disorder.

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