Bring it, David J. Bier!

Umm, why hit a “clanker” with your fists? These guys need some counseling, anger management, something.

So it’s time to buy in?

Keep Singing for The People, Mo Chara! Glad to know your voice!

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Ick!

Thanks for the reminder, I’ll go post over at: https://fedia.io/m/santafe/

Can you define for me the difference in your thinking between vaccine and immune activator?

Seems a reasonable place to start. Where would you suggest preliminary research be done, if not in mice, then where?

Not a single one, well, except the (millions of ) ones going to China.

I believe you are mistaken, as there is a demonstrated reduction in allergic asthma. Please read the paper, it’s fascinating!

BEANS!

I actively boycott all sorts of things, that I’ve never wanted to own. I may even have had a pair of Florsheim shoes, when I was a kid, and my parents needed me to have a ‘suit’ to dress up in, for some wedding, funeral, etc. Now that they are associated with toxic trumpy, they are as dead to me. They could take steps (pun intended) to rehab their image, the goper/maga stench is persistent.

Sort of it IS OTA, as it’s a nasal spray onto the nasal mucosa, and not an injection. Putting the vaccine onto the nasal mucosa, where it is expected to ‘see’ the infectious agent is a clever part of this research. Putting a vax into the patient’s deltoid muscle is a bit of a distance from the nasal mucosa.

I’m working on getting (ok, it’s just arrived, and I need to head off to class) and digesting the paper. I suspect that this is because of the more effective application/regulation of macrophages, CD4+ and CD8+ cells, such that they aren’t over responsive. To keep with the metaphor above, the TRMs are in a dormant state, waiting to be activated, but in this case the activation is much more specific, so it’s not going ‘off the rails’ for every Hombre with a Black Hat, but rather every Hombre with a Black Hat, leather hat band, and a white feather, sort of. I’ve not read beyond the Abstract.

Link above is only to the abstract, with an additional link to figures and tables:

Abstract Traditional vaccines target specific pathogens, limiting their scope against diverse respiratory threats. We describe an intranasal liposomal formulation combining toll-like receptor (TLR) 4 and 7/8 ligands with a model antigen, ovalbumin, that provided broad, durable protection in mice for at least 3 months against infection with SARS-CoV-2 and Staphylococcus aureus. In addition, the vaccine protected mice from other viruses (SARS-CoV-2, SARS, SCH014 coronavirus), bacteria (Acinetobacter baumannii), and allergens. Protection was mediated by persistent ovalbumin-specific CD4+ and CD8+ memory T cells that imprinted alveolar macrophages (AMs), enhancing antigen presentation and antiviral immunity. Following infection, vaccinated mice mounted rapid pathogen-specific T cell and antibody responses and formed ectopic lymphoid structures in the lung. These results reveal a class of “universal vaccines” against diverse respiratory 🩹

The cool thing about this is the stimulation of CD4 & CD8+ memory cells imprinting alveolar (the alveoli of the lungs) macrophages, a type of Tissue Resident Macrophage (TRMs) that will then hang out in that location, where the invaders first appeared, waiting for them to return. Whereupon they will alert the immune system that “those guys” are back, you know what to do. I heard the process explained this way:

TRMs are like that cowboy seemingly snoozing away, at the Old Saloon. Then when “those infectious guys” that had infected one before, and markers for them are imprinted on the TRMs show up, suddenly the guy snoozing away ‘wakes up’, saying “I remember YOU!” and alerts The Posse (Immune System) that it’s time to take action. The version I heard on TWIV was a bit cuter, but I edited this for clarity.

Can we at least save this till Wednesday?

real beans

I’m not certain how long, but it’s been a very long time since I even heard this shoemaker’s name. Boycotting will be so easy.

ALWAYS LOOK BOTH WAYS!