With all the hormones and whatnot inside. Dopamine, adrenaline, melatonin, whatever. Also, there’s this Hunter S. Thompson bit on the… pineal gland?

If it had an effect on you, wouldn’t it be a really messed up high, all over the place? With uppers, downers etc mixed? (Not including the emotional implications of eating raw human brains.)

  • @Nurse_Robot@lemmy.world
    1•8 months ago

    I don’t think that’s correct.

    Does rectal have first-pass effect? In general, drug absorption in the upper part of the rectum is transported to the liver via the portal system and thus undergoes first-pass metabolism, whereas drug absorption in the lower rectum is transported directly to the systemic circulation

    • @medgremlin
      1•8 months ago

      The lower colon really only transports water and a couple of vitamins released by gut biota, so if they’re getting far enough in that more complex molecules would be taken up, that would probably be up into the hepatic portal system.

      The reason “boofing” works for alcohol is because ethanol is actually a rather small molecule, all things considered.