I love genuine questions and people putting in the effort to love and understand each other better. If you come at me just wanting to argue I’m going to troll you back. FAFO.

  • 133 Posts
  • 220 Comments
Joined 3 years ago
cake
Cake day: June 12th, 2023

help-circle



  • I think you need a line break after the second spoiler and I think you are missing a space after the :::

    Wait lemme check:

    spoiler

    Yes

    spoiler no :::

    this doesn’t load in boost but does load in the web version?

    Yeah it’s not just my app the first one renders right. Although weirdly enough now that I open this on web it renders ok but only the first one renders as a proper spoiler in boost. Weird.






  • Honestly the research on exactly why this happens is sparse enough as it is. It’s basically impossible to do truly conclusive studies with tobacco because of how dangerous it is. We can’t even technically conclusively say that tobacco causes cancer because to truly scientifically assert that you’d have to do a randomized controlled trial.

    To have a truly randomized controlled trial you would have to randomly select people from the overall sample and tell them to start smoking for the purposes of the study (otherwise you can’t technically rule out there being some third thing that both causes the cancer and causes people to want to smoke). And because we know tobacco is insanely addictive and are all but that one millimeter short of proving that it causes cancer, no medical ethics oversight body would ever allow a study that requires participants to start smoking.






  • Honestly I feel the same about buspar but some people swear by it. I actually liked the wellbutrin a LOT it just also gave me terrible air hunger. I’ve wondered if the Dextromethorphan would counteract that.

    Lexidrugs (my employer’s pharmacy reference database) only references dyspnea (shortness of breath) specifically for wellbutrin with an incidence of ≥1%. Given that my air hunger never correlated to any outwardly observable signs other than mild tachycardia (no O2 changes), it’s safe to conclude the sensation was neuropsychiatric in origin / somatic anxiety. Both entries do also list the following incidences of adverse reactions relevant to anxiety:

    Wellbutrin (bupropion alone):

    • Agitation - 2-32%
    • Anxiety - 3-8%
    • Akathisia - 2% (I’m particularly sensitive to this side effect)
    • “jitteriness” - 3%
    • nervousness 4-5%

    Auvelity (bupropion + Dextromethorphan):

    • Anxiety 4%

    Now, Auvelity also has a much shorter list overall likely due to it being a much newer and therefore less studied medication. That said I’m seeing a much higher incidence of things like drowsiness with Auvelity (7%) vs Wellbutrin (2-3%). That suggests that the dextromethorphan IS offsetting the stimulating effect of the Bupropion. The question is whether it’ll hit me as a smooth buzz or a delirious haze. Given that the bupropion did improve my attention even with the air hunger I would hope it would be the former but I think I’d want to take a few weeks of vacation to see. Maybe next year.

    OH also: did you take wellbutrin or zyban? Brand name zyban was much more expensive than wellbutrin due to “officially” being approved for nicotine cessation. Although if it was super recent probably not because everybody just started giving their smoker patients wellbutrin off-label, which is one of a few ways doctors can just flip big pharma the bird, lol.





  • It also paralyzes your cilia so it’s not improbable (cilia are the little hairs that line your breathey tubes and rhythmically beat to push gunk up and out). It’s actually why the smokers cough usually gets worse a few days after quitting then stays worse until you’re finished hacking up all the built up tar. Your cilia wake up to your respiratory tract fucking trashed like WHAT THE FUCK IS THIS.